In fact, this is often why people stop taking niacin 1. Niacin flush is a common side effect of taking high doses of niacin supplements. It appears as a flush of red on the skin, which may be accompanied by an itching or burning sensation 1. Niacin is also known as vitamin B3.
As a supplement, niacin is primarily used to treat high cholesterol levels. Nicotinic acid is the supplement form people usually use for this purpose. Niacin flush is a very common side effect of taking the immediate-release form of nicotinic acid. By some reports, virtually every person who takes high doses of nicotinic acid experiences flush 6.
Other medications, including some antidepressants and hormone replacement therapies HRTs , can also trigger flush 1. Niacin flush is a common reaction to high doses of niacin. When niacin flush occurs, symptoms typically set in about 15—30 minutes after taking the supplement and taper off after about an hour. The symptoms mainly affect the face and upper body, and include 9 , 10 :. People generally develop a tolerance to high-dose niacin.
So even if you experience niacin flush when you first start taking it, that will probably stop in time 1 , 8. Niacin flush can appear and feel much like a sunburn. However, symptoms typically go away after an hour. People usually develop a tolerance to the supplements over time. Doctors have long prescribed high doses of niacin to help people improve their cholesterol levels and prevent heart disease 5.
Taking high doses of niacin has been shown to produce the following improvements in blood cholesterol and lipids:. People only experience these positive effects on blood fats when they take therapeutic doses of niacin in the range of 1,—2, mg per day 5. To put that in perspective, the recommended daily intake for most men and women is 14—16 mg per day 9 , Niacin supplements should be treated like a drug and only taken under medical supervision, since they can have side effects.
High doses of niacin are typically used to improve cholesterol and triglyceride counts. They should only be taken under medical supervision, since they carry a risk of side effects. However, high doses of niacin can cause other, more dangerous side effects, although these are rare The most harmful of these is liver damage. The therapeutic role of niacin in dyslipidemia management. J Cardiovasc Pharmacol Ther. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease.
N Engl J Med. Diet and cataract: the Blue Mountains Eye Study. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Effects of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: a randomized trial. Arterial Disease Multiple Intervention Trial. Garcia-Closas R.
Food, nutrient and heterocyclic amine intake and the risk of bladder cancer. Eur J Cancer. Ginsberg HN, reyes-Soffer G. Niacin: a long history, but a questionable future. Curr Opin Lipidol. Multiple-dose efficacy and safety of an extended-release form of niacin in management of hyperlipidemia. Am J Cardiol. Guyton JR. Niacin in cardiovascular prevention: mechanisms, efficacy, and safety. Long-term nutrient intake and early age related nuclear lens opacities. Arch Ophthalmol. Use of vitamin supplements and cataract: the Blue Mountains Eye Study.
Am J Ophthalmol. Toxicity from the use of niacin to beat urine drug screening. Ann Emerg Med. Nutrients and Nutritional Agents. Drug Facts and Comparisons. Louis, MO: ; Facile, one-step production of niacin vitamin B3 and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst. Sahebkar A. Vasc Med. Present-day uses of niacin: effects on lipid and non-lipid parameters.
Expert Opin Pharmacother. Niacin, an old drug with a new twist. J Lipid Res. Surjana D. Damian DL. Nicotinamide in dermatology and photoprotection. Torkos S. Drug-nutrient interactions: a focus on cholesterol-lowering agents. Int J Integrative Med.
Niacin: the evidence, clinical use, and future directions. Curr Atheroscler Rep. Wolerton: Comprehensive Dermatalogic Drug Therapy. Philadelphia, PA: Elsevier Saunders; Negative transcriptional regulation of inflammatory genes by group B3 vitamin nicotinamide. Mol Biol Rep. Study on vitamin B1, vitamin B2 retention factors in vegetables.
Wei Sheng Yan Jiu. Available Forms Vitamin B3 is available in several different supplement forms: Niacinamide Niacin Inositol hexaniacinate. How to Take It Generally, high doses of niacin are used to control specific diseases. The vast majority of people don't need to take niacin supplements because there's plenty of niacin in the foods found in a typical diet, even diets that aren't all that healthy.
Nuts , legumes , eggs , poultry, beef, and seafood are all high in niacin, and it's found in smaller amounts in most other foods. So as long as you're eating every day, you're getting plenty of niacin.
Be careful if you're thinking about taking niacin for your high cholesterol levels. Even though the niacin flush is harmless, large doses of niacin can interact with many different medications.
Long-term use can cause liver damage, skin rashes, gastrointestinal problems, and elevated blood sugar. Looking to lose weight? Our nutrition guide can help you get on the right track. Sign up and get it free! National Institutes of Health. Office of Dietary Supplements. Niacin Fact Sheet for Health Professionals. Updated June 3, Randomized controlled trial of different aspirin regimens for reduction of niacin-induced flushing.
Am J Health Syst Pharm. Niacin: Chemical forms, bioavailability, and health effects. Nutr Rev. Office of Dietary Supplement. Niacin Consumer Guide. Updated July 11, Your Privacy Rights. To change or withdraw your consent choices for VerywellFit.
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