Objective: There are limited data comparing medication strategies in patients with treatment-resistant depression. In this study, we compared the effects of combining citalopram and bupropion-SR versus switching to the other monotherapy in treatment-resistant depression.
Method: This was a naturalistic, open-label cohort study. This is called monotherapy. If that happens, they might try another medication within that class, or switch to another class of antidepressants entirely. Research now suggests that taking antidepressants from multiple classes may be the best way to treat MDD.
In fact, bupropion is one of the most commonly used combination therapy medications. For people experiencing loss of appetite and insomnia, mirtazapine may be an option. Its most common side effects are weight gain and sedation. Research suggests there may be some benefit in treating persistent symptoms in people taking SSRIs with atypical antipsychotics, such as aripiprazole. Carefully consider the pros and cons of antipsychotics with your doctor.
Their side effects may prolong or worsen some symptoms of depression. Research suggests that T3 with a TCA may lead to a faster response to treatment compared with taking a TCA alone, but more research is needed.
The dose typically used for this purpose is 25 micrograms mcg a day of triiodothyronine. D-amphetamine Dexedrine and methylphenidate Ritalin are stimulants used to treat depression. They can be used alone, but they may also be used in combination with antidepressant medications. Stimulants are most helpful when the desired effect is a quick response. People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination.
Success rates of monotherapy treatment are relatively low. Therefore, many researchers and doctors believe the first and best approach to treating MDD is combination treatments. Despite the name, there are still treatments that can….
Trends Neurosci. Celexa label. Food and Drug Administration. Revisions to Product Labeling. Silverman HM. The Pill Book. Bantam Books; Wellbutrin buproprion hydrochloride tablets prescribing information. June Bupropion for attention deficit hyperactivity disorder ADHD in adults. Cochrane Database Syst Rev.
ACOG guidelines on psychiatric medication use during pregnancy and lactation. Am Fam Physician. College of Psychiatric and Neurologic Pharmacists.
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